She disappeared without a trace almost 14 years ago.
The DeSoto County Sheriff's Office hasn't given up trying to find Katherine Lowery or evidence that might point to what might have happened to her.
Many arrows point to an inmate in the state of Wyoming but investigators still need help to solve the case in the Mid-South.
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Lowery was the mother of two who made a horrible choice when it came to love. Police believe Lowery's relationship may have played a factor in her disappearance in 1999.
She lived in a rented house in Olive Branch with Steven DeLoge, her boyfriend. It was the last time anyone ever saw the 27-year-old alive.
"It's kind of like finding a needle in a haystack," DeSoto County Sheriff Det. Jerry Owensby. "If someone wants to be missing they can be missing. They don't have to answer to anyone."
This is where the story gets ... disturbing.
Cheyenne, Wy., Police arrested DeLoge for sexually assaulting Lowery's daughter in November of 1999. Wyoming police say when they questioned the two children about their mother's whereabouts they said they had not seen her since February.
DeLoge was convicted and sentenced to six life sentences for the assaults.
"He is most definitely a person of interest, most definitely," Det. Owensby said.
DeLoge refused to cooperate and for good reason. He's the prime suspect in the disappearance of his own sister, after she ended a romantic relationship during which the two had a child together.
"There is some suspicious activity somewhere," Det. Owensby.
But what about Lowery? What happened to her? Six years ago in 2007, investigators found a human skull but DNA tests showed it was not hers.
The home she rented is gone as the area changed by redevelopment.
Neighbors told police they never heard any fighting between Lowery and DeLoge. Without DeLoge talking, it is a Mississippi mystery.
"We are going to go logically forward," Det. Owensby said. "Ask for your help, ask for people to call in and logically connect the pieces."
The DeSoto County Sheriff has Lowery's DNA on file in case they find remains and need it to identify her.
If you have any information about the disappearance of Lowery you are urged to call the DeSoto County Crime Stoppers at 1-662-429-8411.